Faouzi Dahdouh

Research interest

Toxicology, pharmacology, and molecular biology of natural products, in particular, venoms of venomous animals. This is for the aim of exploring the beneficial effects of these chemicals against oxidative chronic diseases, including cancers. The study includes in vivo and in vitro experimental investigations.

My academic career has been shaped by a strong foundation in toxicology, pharmacology, and molecular biology, with a focus on natural products. Through my work in Algeria, I became deeply interested in the application of these compounds in combating oxidative stress-related diseases, including cancer.

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Fluorescence Microskope

Research progress in Bonn University

The study was performed in the laboratory of food safety of Bonn University for the aim to explore the anticancer activity via induction of cell death and induction reactive oxygen species (ROS) production of venom collected from Algerian bees (Apis mellifera sahariensis) on human cervical cancer cell lines (Hela cells). Here, Hela cells were treated with various concentrations of BV, and then cell death and ROS detection assays were performed. Results revealed that BV effectively induced cell death in association with increased ROS production.

My home university in Algeria is the Higher National School of Technology Education (HNSTE) of Skikda. This institution has provided me with a strong scientific support in toxicology and pharmacology using natural products, including animal venoms and their potential therapeutic applications.

Hagenguth/DAAD, Beispielfoto

Preparation of cell cultures

I chose Bonn University, in particular, the laboratory of food safety led by Prof. Henning Hintzsche as my host institution due to its global reputation for advanced research in natural product pharmacology. This working environment was ideal for enhancing my research on the anticancer potential of Algerian bee venom and for fostering interdisciplinary collaborations that could significantly impact my academic career.

The obtained findings and their benefits for me, and for my research

The findings of the study, increased cell death via production of ROS in Hela cells, contribute significantly to the ongoing search for bee venom with potential anti-cancer properties. This aligns with my broader research goal of investigating other natural products for their therapeutic potential, particularly in oncology.

Hagenguth/DAAD 4 Beispielfoto

Laboratory tests

The research findings on bee venom anticancer activity would be used in therapy for patients as an adjuvant or an alternative treatment after a time-intensive process, starting by preclinical research, and ended by therapeutic efficacy and optimal dosing in humans. This phase could take 4–6 years.

Additionally, I have developed strong laboratory skills, including proficiency in cell culture, cytotoxiicty and cell death assay, and fluorescence microscopy, which are essential tools in cancer research. The success of these experiments has reinforced my confidence in my ability to conduct independent scientific research.

The atmosphere at the Institute of Food Safety at Bonn University greatly contributed to my academic and professional growth. The work there was very convenient, enabling me to gain valuable insights into cutting-edge laboratory techniques and inter-disciplinary approaches, which were essential for advancing my research on the anticancer potential of Algerian bee venom.

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Laboratory of Food Safety, Bonn

I worked closely with my supervisor, Prof. Dr. Henning Hintzsche, and other researchers in his lab. What stood out most regarding the research processes and communication was the institute's emphasis on interdisciplinary collaboration and the transparent sharing of data.

The planned research project for my further academic career

I expect to combine bee venom with existing chemotherapy agents to discover synergistic effects that could lead to more effective treatments with fewer side effects. The in vivo studies will provide crucial data on the safety and pharmacokinetics of bee venom, paving the way for future clinical trials. Also, my research may contribute to the development of bee venom-based formulations as adjunct therapies in clinical settings, providing patients with more effective and less toxic treatment options.

Moreover, the intended research project is a critical step in my career as a cancer researcher, as it will allow me to gain extensive experience in experimental design, molecular biology techniques, and animal model research. By working closely with oncologists and pharmacologists.

Differences between my home country Algeria and Germany

Algeria may provide a more traditional and localized research experience with fewer resources and opportunities for large-scale interdisciplinary collaborations. However, there is potential for meaningful impact through integrating traditional knowledge with scientific innovation. Germany, on the other hand, offers a highly advanced, collaborative, and resource-rich environment with strong funding support, access to cutting-edge technology, and a focus on interdisciplinary cancer research. Germany’s work culture emphasizes innovation, and your work on bee venom could be supported by a more dynamic, globally connected scientific community.

In Bonn, I enjoyed comfortable housing, diverse food options, enriching cultural events, convenient shopping, and warm communication with locals, aided by learning basic German phrases. The city’s welcoming atmosphere made my stay fulfilling beyond academics.

The influence of my research at Bonn university on my academic path

I will acquire advanced research techniques and interdisciplinary knowledge in cancer biology, natural product pharmacology, and therapeutic development. Also, the access to Bonn’s global research network and the opportunity to collaborate with leading scientists will enhance your visibility in the scientific community. Conclusively, my research will position me for postdoctoral opportunities, potential collaborations with pharmaceutical companies, and roles in translational medicine.

Contacts enabling me to complete my research for another stay in Germany

Contact the Alumni Association at Bonn University to learn about research-related events, career development programs, and contacts that could help with my future stays in Germany. Additionally, update my profiles and search for relevant academic and industry professionals in oncology, pharmacology, and natural products. Joining specialized groups and participating in discussions can help me make connections and stay up to date on research opportunities.

The most important cultural and personal experiences kept in memory

Work-Life Balance, Scientific Rigor and Collaboration, and Cultural Diversity. Work-life balance in Germany allowed me to focus on research during structured hours while enjoying cultural events and personal time. Scientific rigor and collaboration at Bonn University enhanced my research on bee venom’s anticancer effects through teamwork and advanced techniques. Additionally, the city’s cultural diversity enriched my experience, broadening my perspective both professionally and personally, and fostering valuable connections in an international scientific community.